A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113nM, rat brain membrane Kd = 0.4-1nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81nM).
Synonyms:5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
Molecular Formula:C₁₉H₂₇N₃O₄S
Solubility:DMSO or EtOH
Primary Target:5-HT4
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
