85-2073-06　GBR 12909 Dihydrochloride 50mg　CAS No:67469-78-7,Free Base: 67469-69-6　217380

特徴

• A potent inhibitor of dopamine active transporter (DAT, Ki = 1nM, IC50 = 40 and 51nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.
• Synonyms:1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
• Molecular Formula:C₂₈H₃₂F₂N₂O•2HCl
• Molecular Weight:450.56 (anhydrous)
• Purity:≥98% (HPLC)
• Appearance:White to off-white solid
• Melting Point:>178°C (dec.)
• Solubility:DMSO (Slightly), Methanol (Slightly)
• Primary Target:DAT
• Primary Target Ki:1nM
• Method for Determining Identity:1H NMR 19F NMR and Mass Spectrometric Analysis
• TLC Conditions:SiO2; Dichloromethane: Methanol: Ammonium Hydroxide: 9:1:0.1; Visualized with UV and KMnO4; Single spot, Rf=0.65
• Elemental Analysis:Calculated: %C: 64.24, %H: 6.55, %N: 5.35
• Chloride Content (Ion Chromatography):As Reported
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.