85-2072-99　g-Secretase Inhibitor XX ((S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine) 500ug　CAS No:209984-56-5　217372

特徴

• A cell-permeable dibenzazepine (dbz) compound that acts as a potent y-secretase inhibitor and significantly lowers both brain and plasma AB40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100umol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50=1.7nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10umol/kg, i.p).
• Synonyms: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
• Formula:C₂₆H₂₃F₂N₃O₃
• Primary Target:g-secretase
• Secondary Target:Notch processing (IC50 = 1.7nM in SupT1 cells)
• Solubility:DMSO
• Molecular Weight:463.4
• Storage and Stability:Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.