A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate.
Molecular Formula:C₂₉H₃₁NO₈S
Enantiomeric purity:≥ 99% (a/a)
Purity (DC(BAW0)):≥ 97%
Assay (HPLC, area%):≥ 95% (a/a)
Solubility: (1 mmole in 4 ml DMF)clearly soluble
Molecular Weight:553.62g/mol
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
