A cell permeable thioxothiazolindine compound that reversibly inhibits FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50 = 3.99, 7.55, and 231.1uM, respectively), while exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC50 = 50uM). Shown not to affect Caco-2 viability, membrane permeability, or glucose transport.
Synonyms:Fatty Acid Transport Protein 2 Inhibitor, (5E)-5-((3-bromo-4-hydroxy-5-methoxyphenyl)methylene)-3-(3-chlorophenyl)-2-thioxothiazolidin-4-one, CB2
Molecular Formula:C₁₇H₁₁BrClNO₃S₂
Primary Target IC50:8u
Solubility:DMSO
Purity:≥99% (HPLC)
Form:Supplied as a yellow solid.
Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
