85-2072-71　［取扱停止］ERK Kinase Kinase 5 Inhibitor (N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide, 2HCl, N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(2-methyl-2-propanyl)benzamide, 2HCl, 4-tert-Butyl-N-(6-(1H-imidazol-1-yl)imidazo(1,2-a)pyridin-2-yl)benzamide, 2HCl, Apoptosis Signal-Regulating Kinase 1 Inhibitor, ASK-1 Inhibitor, MAP Kinase Kinase Kinase 5 Inhibitor, MAP3K5 ...　CAS No:1005775-56-3　217346

特徴

• A cell-permeable imidazopyridine compound that acts as a potent, ATP-binding site-targeting ASK1/MEKK5-selective inhibitor (IC50 = 14 and 500nM, respectively, against ASK1 and ASK2/MEKK6), while exhibiting much reduced or no activity toward a panel of 195 other kinases. Shown to inhibit STZ- (1 mM) induced JNK and p38 phosphorylation in INS-1 pancreatic beta cells (IC50 <300nM) and be orally available in rats in vivo.
• Molecular Formula:C₂₁H₂₁N₅O • 2HCl
• Primary Target:ASK1/MEKK5
• Primary Target IC50:14 and 500nM, respectively, against ASK1 and ASK2/MEKK6
• Molar Mass:432.4
• Solubility:DMSO or H2O
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：~99% (HPLC)
• Form：Supplied as a white powder.
• Molecular Formula：C₂₁H₂₁N₅O • 2HCl
• Molecular Weight Non Ab：432.4
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：1005775-56-3

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