85-2072-55　DUB Inhibitor V, PR-619 25mg　CAS No:21645-32-1　217329

特徴

• A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains.
• Synonyms:PR619; UCH-L1 Inhibitor IV; UCH-L3 Inhibitor II; UCH-L5/UCH37 Inhibitor III; USP5 Inhibitor II; USP7 Inhibitor I; USP9X Inhibitor II; USP14 Inhibitor IV; USP14 Inhibitor IV; USP47 Inhibitor I; 2,6-Diaminopyridine-3,5-bis(thiocyanate); 3,5-Dithiocyanatopyridine-2,6-diamine
• Molecular Formula:C₇H₅N₅S₂
• Molecular Weight:223.3
• Purity:≥99% (HPLC)
• Appearance:Tan solid
• Solubility:DMSO (50mg/ml)
• Proton NMR:Conforms
• LC-MS:Conforms
• Carbon:35-38%
• Hydrogen:1.5-3.5%
• Nitrogen:29-32%
• Sulfur:27-30%
• Water by CHN (mol):≤2mol
• Storage and Stability:Store at 4°C. Stable for 6 months after receipt.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.