85-2072-43　［取扱停止］Dafadine-A ((5-((2,6-Dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone, 4-(1-((5-((2,6-Dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A) 25mg　217310

特徴

• A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20uM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C. elegans (at ~25uM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%.
• Synonyms:DAF-9 Cytochrome P450 Inhibitor, Dafadine-A, (5-((2,6-Dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone, 4-(1-((5-((2,6-Dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine
• Molecular Formula:C₂₃H₂₅N₃O₃
• Solubility:DMSO
• Molar Mass:391.5
• Purity:≥98% (HPLC)
• Appearance:Supplied as a light beige powder.
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.