A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO; [D-ser] = 10mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50mM) exposure (ED50 ≤3.95uM), while exhibiting little affinity toward nMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12h b.i.d. oral dosages) in vivo.
Formula:C₅H₆N₂O₂
Solubility:DMSO
Primary Target:DAAO
Primary Target IC50:910nM
Molar Mass:126.11
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
