A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48h; 5ug/ml), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24h; 10ug/ml), indicative of Ras-Raf-MEK signaling pathway activation.
Alternate Names:(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron protein Upregulator, Cuspin-1
Molecular Formula:C₁₃H₁₀BrNO
Solubility:DMSO
Primary Target:Ras
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
