85-2072-27 ［取扱停止］CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4’-bromophenyl)amide (3’’-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III) 10mg 217289
85-2072-27 ［取扱停止］CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4’-bromophenyl)amide (3’’-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III) 10mg 217289
A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50=2.2 and 3.5nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50=52nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of P and CaMKII at 1uM.
Synonyms:(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
Molecular Formula:C₁₆H₁₂BrClN₂O₂
Solubility:DMSO (100mg/ml)
Purity:≥95% (HPLC)
Appearance:Supplied as a yellow powder.
Storage and Stability:Lyophilized powder may be stored at 4°C. Stable for 12 months after receipt at 4°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
