85-2072-26　CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide) 10mg　217284

特徴

• A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies.
• Alternate Name:N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide
• Molecular Formula:C₁₇H₉F₇N₄O
• Primary Target:Orai3
• Primary Target IC50:490nM
• Molar Mass:418.3
• Solubility:DMSO
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：≥99% (HPLC)
• Form：Supplied as a light beige solid.
• Molecular Formula：C₁₇H₉F₇N₄O
• Molecular Weight Non Ab：418.3
• EU Commodity Code：38220090
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