A positive allosteric modulator selective for NR2C/D containingnMDA receptors (EC50 = 2.7 and 2.8uM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containingnMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
Formula:C26H26ClNO5
Solubility:DMSO
Primary Target:NMDA receptors
Molar Mass:467.94
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.