85-2072-08　Cdk4 Inhibitor V (4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione) 5mg　CAS No:943746-57-4　217265

特徴

• A cell-permeable pyridinylmethylamino-isoquinoline dione compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of Cdk4/D1 activity with selectivity over Cdk2/E and Cdk1/B (IC50=0.03, 1.6 and 25.3uM, respectively). Shown to block the phosphorylation of Rb and induce growth arrest in HCT116 and MCF-7 cells (IC50=0.73 and 0.88uM). Displays desirable metabolic stability in rat liver microsomes and in the presence of NADPH and UDPGA cofactors (t1/2 > 30mins).
• Molecular Formula:C₁₉H₁₈IN₃O₄
• Solubility:DMSO
• Molecular Weight:479.3
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：5mg
• Grade：Highly Purified
• Purity：~98% (HPLC)
• Form：Supplied as a caramel powder.
• Molecular Formula：C₁₉H₁₈IN₃O₄
• Molecular Weight Non Ab：479.3
• EU Commodity Code：38220090
• この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：943746-57-4

• 【試薬に関するお問合せ】
• アズワン株式会社 試薬・プロセス材料グループ
• TEL：06-6447-8641
• FAX：06-6447-8642
• E-mail：[email protected]