85-2072-03　Cdc2-Like Kinase Inhibitor IV (KH-CB19) 5mg　CAS No:1354037-26-5　217260

特徴

• A cell-permeable N-methylindolyl-enaminonitrile compound that acts as a potent, non-ATP mimetic binding and reversible inhibitor of Clk1 and Dyk1A (IC50=19.7 and 55.2nM, respectively) with moderate to excellent selectivity over Clk3 (IC50=530nM) and against 71-kinases. Shown to suppress phosphorylation of Ser/Arg-rich (SR) proteins, regulate alternative splicing and lower both full-length and alternatively spliced human tissue factor isoforms much more efficiently than Cdc2-Like Kinase Inhibitor, TG003 in HMEC-1 cells.
• Synonyms:(E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, Clk Inhibitor IV
• Molecular Formula:C₁₅H₁₃Cl₂N₃O₂
• Molecular Weight:338.2
• Purity:≥99% (HPLC)
• Appearance:Off-white to light yellow solid
• Solubility:DMSO (50mg/ml)
• Method for Determining Identity:Proton NMR and Liquid Chromatography-Mass Spectrometry
• Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -80°C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.