An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50=10uM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50=2.1uM).
Synonyms:ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
Molecular Formula:C₁₈H₂₁NO₄S
Molecular Weight:347.43
Solubility:DMSO (50mg/ml, pale yellow solution)
Purity:≥98% (HPLC)
Appearance:Off-white solid.
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Lyophilized and reconstituted products are are stable for 6 months after receipt. Store at -20°C. Light sensitive.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
