A selective alpha-2A-adrenoceptor antagonist (Ki = 1.7nM and 144.5nM at alpha-2A and alpha-2B-adrenergic receptors respectively). Has been used to study regulation of neurotransmitter release from sympathetic nerves and shown to increase hippocampal noradrenaline release following systemic administration.
Molecular Formula:C₁₃H₁₇N₃ • C₄H₄O₄
Solubility:H2O
Primary Target:→2A-adrenoceptor
Primary Target Ki:1.7nM and 144.5nM at →2A and →2B-adrenergic receptors respectively
Molecular Weight:331.37
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.