85-2071-50　［取扱停止］ATR Inhibitor III, ETP-46464 (ATM Inhibitor III, mTOR Inhibitor XIII, PI 3-K Inhibitor XIX, ETP46464, 2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATM and Rad3-Related Inhibitor III, Ataxia-Telangiectasia Mutated Inhibitor III, DNA-PK Inhibitor VI) 10mg　CAS No:1345675-02-7　217199

特徴

• A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-K-alpha, and ATM (IC50 = 0.6, 14, 36, 170, and 545nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500nM) over ATM or DNA-PK activity (IC50 > 5uM) in U2OS cells, while exhibiting much reduced or little potency toward a panel of 26 other kinases (>55% inhibition at 5uM). Shown to synergize with UCN-01 in replicative stress induction in S-phase replicating U2OS (1.5-, 61-, and 190-fold of control RS, respectively, with 1uM ETP-46464, 50nM UCN-01, or combined treatment).
• Synonyms: 2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATM and Rad3-Related Inhibitor III, Ataxia-Telangiectasia Mutated Inhibitor III, DNA-PK Inhibitor VI, ATM Inhibitor III, mTOR Inhibitor XIII, PI 3-K Inhibitor XIX, ETP46464
• Formula:C₃₀H₂₂N₄O₂
• Primary Target:ATR
• Primary Target IC50:14nM
• Solubility:DMSO
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.