A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1uM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4uM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50=30mg/kg; 5 times/wk for 3 wks via p.o.) in vivo.
Formula:C₁₀H₈ClNO
Molecular Weight:193.6
Solubility:DMSO (100mg/ml)
Purity:≥98% (HPLC)
Appearance:Supplied as a pink solid.
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
