85-2071-23　AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) 5mg　CAS No:927887-18-1　217162

特徴

• A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min).
• Synonyms:P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353
• Molecular Formula:C₁₄H₁₈ClIN₄O₂
• Solubility:DMSO
• Primary Target:P2X3
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：5mg
• Grade：Highly Purified
• Purity：≥99% (HPLC)
• Form：Supplied as a light brown powder.
• Molecular Formula：C₁₄H₁₈ClIN₄O₂
• EU Commodity Code：38220090
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• CAS No ：927887-18-1

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