85-2071-15　［取扱停止］Adenosine A2A/A1 Receptor Antagonist (2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl) 10mg　217153

特徴

• A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA.
• Synonyms:2-Amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]-pyrimidin-5-one, diHCl
• Formula:C₂₃H₂₂N₄O₃ •2HCl
• Molecular Weight:475.4
• Solubility:DMSO (10mg/ml, clear, yellow solution)
• Purity:≥97% (HPLC)
• Appearance:Light yellow solid.
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.