Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50=900nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50=25uM).
Molecular Formula:C₁₆H₁₄ClN₅O₆PS · Na
Solubility:H2O (10mg/ml)
Molecular Weight:493.8
Appearance:White solid
Purity:≥98% (HPLC)
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
