85-2071-01　Acidic Mammalian Chitinase Inhibitor, Bisdionin F 5mg　CAS No:917877-86-2　217138

特徴

• A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50=0.92uM and Ki=0.42uM for hAMCase, and IC50=2.2uM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.
• Synonyms: 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione, AMCase Inhibitor
• Formula:C₁₆H₁₈N₈O₄
• Molecular Weight:386.4
• Solubility:DMSO (5mg/ml, clear, nearly colorless solution)
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.