A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Synonyms:3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
Molecular Formula:C₃H₅NO₄
Solubility:DMSO or EtOH
Molecular Weight:119.1
Storage and Stability:Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
