85-2069-89　PF-562271 5mg　CAS No:717907-75-0　215890

特徴

• Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections.
• Synonyms:PF562271, N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide Hydrochloride
• Molecular Weight:507.5
• Molecular Formula:C21H20F3N7O3S
• Target:FGFR
• Kinase Group:RTK
• Substrate:Tyrosine
• Appearance:Supplied as a solid.
• Purity:≥95%
• Solubility:DMSO or ethanol
• Storage and Stability:Store short term at 4°C. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.