Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin. PTH (aa7-34), is a PTH/PTHrP receptor antagonist, which can stimulate hair growth and epidermal proliferation in mice.
Source:Recombinant protein corresponding to human PTH, a single, non-glycosylated, polypeptide chain containing 28aa, expressed in E. coli.
Molecular Weight:~3.38kD
Biological Activity:Calculated by UMR106 cell/cAMP method corresponding to a specific activity of ~1.0x104Units/mg.
AA Sequence:Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe
Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：50ug
Source Antigen：Recombinant, E. coli
Grade：Highly Purified
Purity：~97% (RP-HPLC, SDS-PAGE)
Form：Supplied as a lyophilized powder in 20mM PBS, pH 7.0, 4% mannitol. Reconstitute with 500ul sterile ddH20.
