Ovarian cancer Antigen (CA125) is a high molecular weight (~200kD) mucin-like glycoprotein and is expressed by greater than 80% of nonmucinous epithelial ovarian carcinomas (EOC). This EOC is found in the most serious, endometriod and clear cell carcinomas of ovary(1). Epithelial ovarian cancer (EOC) is the most common cause of death from gynecologic malignancy in the United States and has an over-all 5 year survival rates of less than 30% stages I diseases, 5-year survival rates of 80% to 90% are achieved.
The ovarian cancer assay may have the following clinical application:1. EOC for monitoring tumor growth serum EOC level correlate with clinical disease status in over 90% of cases in which EOC is elevated in preoperative(2) serum sample a rising serum EOC 125 level is therefore, an extremely reliable indicator of recurrent or progressive disease
2. EOC 125 as a prognostic indicator for ovarian cancer-after cytoreductive surgery and during chemotherapy the level of EOC can provide an early indicator of prognosis(3)
3. EOC might have role as a screening test for the early detection of ovarian cancer.
Source:CA125 antigen, from Ovarian carcinoma cell line
Contaminants:CA19-9: <0.2%CA15-3: 1%
Activity:~150,000 units/ml (Centocor RIA) or ~125,000 units/ml (Elecsys).
Applications:Suitable for use in RIA and Western Blot. Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：10KU
Source Antigen：Ovarian carcinoma cell line
Grade：Purified
Purity：Purified
Form：Supplied as a lyophilized powder from PBS, pH 7.2, 0.05% sodium azide. Reconstitute with sterile PBS.
