Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44aa peptide hormone produced in the arcuate nucleus of the hypothalamus. GHRH stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. The GHRHR is a member of the secretin family of G protein-coupled receptors, and is located on chromosome 7. This protein is transmembranous with seven folds, and its molecular weight is ~44kD. GHRH is released from neuro secretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo- hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion. GHRH also stimulates the production of GH. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. GHRH increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone.
Source:Synthetic human Growth Hormone Releasing Hormone, corresponding to the N-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting of 44aa residues.
Molecular Weight:~3.358kD
Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：250ug
Source Antigen：Synthetic
Grade：Highly Purified
Purity：Highly Purified (~95%)
Form：Supplied as a lyophilized powder in 0.1mg sodium phosphate monobasic, 1.6mg sodium phosphate dibasic. No preservative added.
