Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropesin the anterior pituitary gland. FSH and LH act synergistically in reproduction: In women, in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle. Like its partner, LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin- releasing hormone (GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.
Source:Follicle Stimulating Hormone, from Urine of post-menopausal women
Activity:~626IU/mg powder
Contaminents:<0.1%: hCG, 0.5% TSH, 0.5% LH, 0.5% GH and 0.5% Prl. Free of HbsAg, antibodies to HIV and HCV.
Specific Activity:~10,000 IU/mg protein (IRP reference preparation 68/140).
Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：10ug
Source Antigen：Urine of post-menopausal women
Grade：Highly Purified
Purity：~98% (RP-HPLC, SDS-PAGE)
Form：Supplied as a lyophilized powder. No preservative added. Reconstitute with sterile ddH2O to ~0.1mg/ml.
