CD21 is expressed strongly on mature B cells, follicular dendtritic cells and weakly on immaturethymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFN-alpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form alarge signal-transduction complex involved in B cell activation.
Source:Recombinant protein corresponding to aa21-971 from human CD21, fused to his-tag, expressed in CHO cells.
Molecular Weight:~135kD
Applications:Suitable for use as Positive Control for ELISA and Western Blot. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：2ug
Source Antigen：Recombinant, CHO cells
Grade：Highly Purified
Purity：~95% (SDS-PAGE)
Form：Supplied as a liquid in PBS, pH 7.4. No preservative added.
