Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serpin superfamily. It inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. Alpha 1- antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.
Source:Alpha 1 Antichymotrypsin, from human plasma
Molecular Weight:~68kD
Applications:Suitable for use as antigens for ELISA and Western Blot. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：100ug
Source Antigen：Human plasma
Grade：Highly Purified
Purity：Highly Purified (~99%)
Form：Supplied as a lyophilized powder in 0.02M NaHCO3. No preservative added. Reconstitute with sterile 0.15M sodium chloride, pH 7.0.
