Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-κB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
Recombinant protein corresponding to aa1-1054 from human Jagged-2, fused at the C-terminus to the Fc portion of human IgG, expressed in HEK 293 cells.
Endotoxin:≤0.1EU/ug (LAL test, Lonza)
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：10ug
Source Antigen：Recombinant, HEK 293 cells
Grade：Purified
Purity：≥90% (SDS-PAGE)
Form：Supplied as a lyophilized powder from PBS, 0.02% CHAPS. Reconstitute with 100ul sterile ddH2O.
