85-2062-79　Angiopoietin-like Protein 8, Recombinant, Mouse, Fc Portion, Human (Betatrophin, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL) 10ug　208518

特徴

• Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198aa that promotes beta cell proliferation and improves glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Although the mechanism of action of betatrophin is unknown and its receptor is still to be discovered, identification of this new protein as a hormone controlling beta cell replication and beta cell mass opens a new door to a potential future diabetes therapy.
• Source:Recombinant protein corresponding to aa22-198 from mouse betatrophin, fused at the C-terminus to the Fc portion of human IgG, expressed in HEK 293 cells.
• Molecular Weight:~50kD
• Endotoxin:<0.1EU/ug (LAL test, Lonza)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.