85-2061-83　Resiquimod (R-848, S 28463) 50mg　CAS No:144875-48-9　207380

特徴

• Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-kappaB. NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I. Upregulator of the opioid growth factor receptor. Used in the treatment of skin lesions such as herpes simplex virus.
• Synonyms:1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 4-Amino-2-(ethoxymethyl)-1-(2-hydroxyisobutyl)imidazo[4,5-c]quinoline; 4-Amino-2-ethoxymethyl-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; R 848; Resiquimod; S 28463
• Molecular Formula:C₁₇H₂₂N₄O₂
• Molecular Weight:314.4
• Appearance:White to off-white powder
• Purity:≥98%
• Solubility:Soluble in DMSO, dichloromethane or methanol. Slightly soluble in acetonitrile or ethyl acetate.
• Storage and Stability:Store at -20°C.. Stable for 12 months after receipt. Light sensitive.