85-2061-77　［受注停止］Rebeccamycin (NSC 359079, BRN 4732638) 250ug　207378

特徴

• Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells).
• Synonyms:NSC 359079; BRN 4732638, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
• Source:Streptomyces sp.
• Molecular Formula:C₂₇H₂₁Cl₂N₃O₇
• Solubility:DMSO
• Molecular Weight:570.4
• Method for Determining Identity:Proton NMR
• Purity:≥98% (HPLC)
• Appearance:Supplied as a yellow solid.
• Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.