85-2061-32　PARP3, Recombinant, Human, His-Tag (Poly [ADP-ribose] Polymerase 3, PARP-3, hPARP-3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] Synthase 3, pADPRT-3, ADPRT3, ADPRTL3) 10ug　207331

特徴

• PARP-3 is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
• Recombinant protein corresponding to full length human PARP-3, fused to a HA-tag and a His-tag, expressed in Sf21 cells.
• Biological Activity:≥10U/mg (only monoADP-ribosyl transferase activity)
• Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.