85-2061-19　Ophiobolin A (Cochliobolin A, Ophiobalin, NSC 114340) 100ug　207314

特徴

• Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport.
• Source:Bipolaris leersia
• Formula:C25H36O4
• Solubility:Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in H2O.
• Molecular Weight:~400.6
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with ethanol, methanol, DMSO or dimethylformamide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.