85-2061-08　Necrostatin-1 5mg　CAS No:4311-88-0　207297

特徴

• Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models.
• Alternate Names:Nec-1; MTH-Trp; MTH-DL-Tryptophan; Methyl-thiohydantoin DL-tryptophan; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
• Molecular Formula:C₁₃H₁₃N₃OS
• Solubility:DMSO, ethanol or dimethylformamide. Sparingly soluble in aqueous buffers. For a maximum solubility in aqueous buffers, 207297 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. The solubility is ~0.5mg/ml in a 1:1 solution of DMF:PBS (pH 7.2). Store aqueous solutions not longer than one day.
• Note:In solution the product slightly tautomerizes. In polar solvents there is more enol form while in non-polar solvents there is more keto form.
• Molecular Weight:259.3
• Purity:≥98% (HPLC)
• Appearance:Off-white to yellow solid.
• Storage and Stability:Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.