85-2060-80　［取扱停止］Manumycin A 1mg　CAS No:52665-74-4　207273

特徴

• Antibiotic. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50= 30nM). Does not affect geranylgeranyltransferase (IC50=180uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM).
• Source:Streptomyces parvulus
• Formula:C31H38N2O7
• Solubility:DMSO or methanol; insoluble in H2O.
• Molecular Weight:550.6
• Method for Determining Identity:Proton NMR
• Purity:≥98% (HPLC)
• Form:Supplied as a yellow to brown powder.
• Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.