85-2060-79　Mannosylceramide, alpha 1mg　CAS No:320610-63-7　207272

特徴

• Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24). Vα14 NKT cells recognize α-GalCer presented by CD1d. NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver. They recognize α-ManCer presented by MR1 (Major histocompatibility complex, class I-related) and respond with production of large amounts of immunoregulatory cytokines.
• Alternate Names:α-ManCer; α-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(α-D-mannopyranosyl)-1,3,4-octadecanetriol; α-D-Galactopyranoside
• Molecular Formula:C50H99NO9
• Solubility:Pyridine or warm DMSO
• Molecular Weight:858.3
• Appearance:White to off-white solid
• Purity:≥95% (TLC)
• Storage and Stability:Store at -20°C. After reconstitution, prepare aliquots and store at -20°C. Aliquot into glass vials. For maximum recovery of product, centrifuge the original vial prior to removing the cap.