85-2060-71　Loxoribine 5mg　CAS No:121288-39-9　207261

特徴

• Guanosine analog derivatized at position N7 and C8. Very potent immunostimulatory compound that increases cytokine production. Antitumor and antiviral activity compound. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7). Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8. Induces autophagy and autophagy-induced cell death in Caco-2 cells. Shows adjuvant activity to increase the effectiveness of vaccines.
• Synonyms:7-Allyl-8-oxoguanosine; RWJ 21757, 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione
• Molecular Formula:C₁₃H₁₇N₅O₆
• Solubility:DMSO (30mg/ml) or water (10mg/ml).
• Molecular Weight:339.3
• Melting Point:227-230°C
• Purity:≥97%
• Appearance:Supplied as a white to off-white powder.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile DMSO or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.