85-2060-69　Leucettine L41 ((5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one) 5mg　CAS No:1112978-84-3　207259

特徴

• Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
• Formula:C17H13N3O3
• Solubility:DMSO or ethanol
• Molecular Weight:~307.3
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：5mg
• Grade：Highly Purified
• Purity：~98% (NMR)
• Form：Supplied as a beige solid.
• Molecular Formula：C17H13N3O3
• Molecular Weight Non Ab：307.3
• EU Commodity Code：38220090
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• CAS No ：1112978-84-3

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