85-2060-41　Herbimycin A (Antibiotic TAN 420F, (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin) 100ug　CAS No:70563-58-5　207220

特徴

• Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation of phospholipase C-gamma1. Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Neuroprotective. Antiparasitic, antischistosomal agent. Antiviral. Increase microtubules sensitivity to cold in plants.
• Alternate Names:Antibiotic TAN 420F; (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin
• Source:Streptomyces sp.
• Molecular Formula:C30H42N2O9
• Solubility:Soluble in ethanol, methanol DMSO or dimethylformamide. Poorly soluble in H2O.
• Molecular Weight:574.7
• Purity:≥99% (HPLC)
• Appearance:Supplied as a yellow solid.
• Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 12 months after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.