85-2060-21　Ganglioside GD3, Disodium Salt 500ug　CAS No:62010-37-1　207200

特徴

• Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD3 induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis. It modulates the activity of Src-family tyrosine kinase Lyn and cell apoptosis. It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation.
• Synonyms:GD3•2Na, Disialoganglioside GD3•2Na; a-Neu5Ac-(2-8)-a-Neu5Ac-(2-3)-beta-Gal-(1-4)-beta-Glc-(1-1)-Cer
• Sequence:a-Neu5Ac-(2-8)-a-Neu5Ac-(2-3)-beta-Gal-(1-4)-beta-Glc-(1-1)-Cer
• Source:bovine brain
• Molecular Formula:C70H123N3O29•2Na
• Molecular Weight:~1470.8, 46.0 (calculated on sphingosine C18:1 and stearic acid
• Appearance:White to off-white solid
• Purity:≥98% (TLC)
• Solubility:H2O or chloroform:methanol (2:1)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.