85-2059-99　FNDC4, Recombinant (Fibronectin Type III Domain-containing Protein 4, Fibronectin Type III Repeat-containing Protein 1, FRCP1, UNQ6389/PRO21134) 10ug　207186

特徴

• Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.
• Source:Recombinant protein corresponding to the extracellular domain of human FNDC4, aa45-167/ mouse FNDC4, aa41-163, untagged, expressed in E. coli.
• Molecular Weight:~16kD
• Endotoxin:<0.01EU/ug purified protein (LAL test; Lonza)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.