85-2059-08　Calphostin C (UCN 1028C, PKF115-584, Cal-C) 1mg　CAS No:121263-19-2　207099

特徴

• Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion.
• Source:Cladosporium cladosporioides sp.
• Synonyms:UCN 1028C, PKF115-584, Cal-C
• Molecular Formula:C44H38O14
• Molecular Weight:~790.8
• Purity:~95% (HPLC)
• Appearance:Supplied as a dark red to brown solid
• Solubility:Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in H2O.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute and aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.