85-2059-01　Borrelidin (Treponemycin, U 78548, C2989) 1mg　CAS No:7184-60-3　207093

特徴

• Macrolide antibiotic. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50=0.8nM). Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Antimalarial.
• Synonyms:Treponemycin; U 78548; C2989
• Source:Streptomyces sp.
• Formula:C28H43NO6
• Method for Determining Identity:Proton NMR
• Solubility:DMSO or methanol
• Molecular Weight:489.6
• Purity:≥98% (HPLC)
• Appearance:White to off-white powder.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.