Antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antibacterial, antifungal, insecticidal and antihelmintic. Potential anti-osteoporotic agent in treating bone lytic diseases. Neuroprotection inducer.
Source:Streptomyces sp. Gö 14F
Formula:C39H60O12
Method for Determining Identity:Proton NMR
Solubility:100% ethanol, methanol, DMSO or dimethyl formamide. May undergo transformation to methyl ketal on long term storage in methanol. Recommend the use of fresh solutions.
Molecular Weight:~720.9
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
