85-2058-43　Angiopoietin-2, Recombinant, Mouse, aa19-496 (Ang-2, Ang2, Angpt2, Agpt2) 10ug　207051

特徴

• Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
• Source:Recombinant protein corresponding to aa19-496 from mouse Angiopoietin-2, fused to FLAG®-tag at N-terminal, expressed in HEK 293 cells.
• Molecular Weight:~70kD (SDS-PAGE)
• Endotoxin:<0.05EU/ug purified protein (LAL test; Lonza)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.