85-2058-21　AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) 10mg　CAS No:924416-43-3　207034

特徴

• Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.
• Solubility:Soluble in DMSO, 100% ethanol or methanol. Insoluble in H2O.
• Storage and Stability:May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO, 100% ethanol or methanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：~98% (HPLC)
• Form：Supplied as colorless crystals.
• Molecular Formula：C27H28N2O3
• Molecular Weight Non Ab：428.5
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：924416-43-3

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